Gabriel Jesus and Alex Telles will both miss the remainder of Brazil's World Cup campaign due to injury.
The Arsenal striker is likely to spend around three-to-four weeks on the treatment table after feeling pain in his right knee during the loss to Cameroon on Friday night. As first reported by Brazilian outlet Globo, it is an injury the ex-Manchester City man has carried around for a while.
It spells the end of his hopes of finally putting to bed his World Cup hoodoo, having failed to score at all in Russia four years ago and without a goal during his limited amount of minutes in Qatar.
The situation is more dire for Telles, who is currently on loan with LaLiga side Sevilla from parent club Manchester United. The full-back is expected to undergo surgery after further tests have assessed just how bad the damage is, with his problem in a similar area to Jesus'.
Brazil were widely tipped as favourites to lift football's most coveted trophy, but they have had rotten luck with injuries so far. Talismanic forward Neymar is still a doubt for their round of 16 tie against South Korea on Monday after hurting his ankle on match-day one.
From a club perspective, Mikel Arteta will be sweating over the status of Jesus. Arsenal are back in action against West Ham on Boxing Day, which is likely to come too soon for Jesus, who will now view the opening exchanges of the new year as his target return date.
Despite the defeat and the damaging injury news, Brazil will have to soldier on as boss Tite admitted they "have to suffer".
Speaking after the game against Cameroon, the Brazil manager claimed: "We feel the loss and we must feel the loss when we lose, as we won the first two matches it gives you a second chance but usually in the World Cup that is not the case.
"The Brazilian coach who lost to the first African team, that is now in my history. “We have to suffer for 24 hours and then we have to start getting ready."