
When we last saw the Buffalo Bills and Tennessee Titans face off, it was October 18, 2021 — Week 6 of the season. Tennessee pulled off a thrilling 34-31 comeback win, scoring 10 unanswered points in the fourth quarter, and pointing running back Derrick Henry at Buffalo’s nickel-heavy (and run-light) defense as if Henry was the biggest possible power tool — which, of course, he was. Henry led the way for the Titans as he had the two seasons before, and as he did until his season was halved by injury. He ran 20 times for 143 yards and three touchdowns, including the game-decider with 3:05 remining.
While the Bills are well aware of what Henry can do to them when healthy, it might not be the main story as these two teams get ready for their Monday Night Football matchup (7:15 EST, Buffalo’s Highmark Stadium, ESPN/ESPN2). Henry has not yet looked like the back he was before missing half the 2021 season with a foot injury. Quarterback Ryan Tannehill is coming off a season in which he led the league in third-down interceptions with 11. Tennessee’s receiver corps is very much in flux after the A.J. Brown trade, and a defense that used to be one of the NFL’s best has some questions marks in both pressure and coverage.