Novak Djokovic raged about a "drunk" fan and struggled with his injured hamstring but on a day where big names tumbled, the nine-times champion stood tall.
Earlier, Australia's Alexei Popyrin put on a serving display to produce one of the biggest upsets of the tournament as the world number 113 defeated world number nine Taylor Fritz.
The draw was earlier blown wide open by second seed Casper Ruud's upset loss to Jenson Brooksby.
