Madison Keys' dream of completing a famous double is over as the Australian Open victor became the 18th women's seed and latest grand slam champion to be dumped out of this shock-laden Wimbledon.
But Aryna Salabenka, the No.1 seed, remains on pole in her quest for a maiden triumph in the grass-court slam after winning an enthralling Friday night Centre Court duel with home heroine Emma Raducanu.
The sixth-seeded American Keys was sent crashing on Independence Day 6-3 6-3 by tough German veteran Laura Siegmund as she became the fifth of the top-six seeds, and sixth out of the top 10, to be sent spinning out of the event on Friday.