There's a strong argument that Wednesday night's clash at the Etihad Stadium is Arsenal's biggest game perhaps since their first and only appearance in a Champions League final.
The reward for beating Manchester City away from home - something the north London outfit have not managed in the Premier League since January 2015 - will be an eight-point lead at the top of the table and firmly back in control of the title race after three straight draws.
Based on recent history and current form, the odds are stacked heavily against the Gunners. But it's worth pointing out that under Mikel Arteta, hoodoos at Stamford Bridge, Old Trafford and away at Tottenham have come to an end, not to mention claiming a point at Anfield earlier in the month.
