Aaron Ramsdale starts for Arsenal after Matt Turner’s late groin issue means the Premier League starter makes his first appearance in European competition. Turner trained ahead of the trip and so his absence is unexpected.
Fabio Vieira and Martin Odegaard both start again for the first time since the 1-0 away win to Bodo/Glimt. However, it is expected Vieira will play on the right of a front three including Gabriel Martinelli and Eddie Nketiah.
Odegaard will play in his usual right-sided central midfield role with Granit Xhaka and Albert Sambi Lokonga in support. Another chance for the Belgian to show his quality in a tough away ground.
READ NEXT: Arsenal vs PSV LIVE: Kick-off time, TV channel, team news, live stream details
The back line sees both Takehiro Tomiyasu and Kieran Tierney start this match with Ben White and Gabriel Magalhaes being rested. Rob Holding and William Saliba are the starting central defensive pair.
Arsenal know that a win or draw in this game will see them guarantee top spot. Nketiah’s starting position centrally will be a boost for the player who when partnered with the rested Gabriel Jesus must make do with a wider role.
Once again the clear absentee is Cedric Soares despite the midweek rotation. The Portuguese international makes the bench alongside the likes of Reiss Nelson and youth players Catalin Cirjan, Bradley Ibrahim and Matt Smith
Starting XI: Ramsdale; Tomiyasu, Holding, Saliba, Tierney; Lokonga, Xhaka, Odegaard; Martinelli, Vieira, Nketiah
READ NEXT:
Every Arsenal Europa League permutation with chance to benefit from major UEFA rule change
Mikel Arteta transfer decision justified as ex-Arsenal man suffers Sadio Mane embarrassment
What happened between Gabriel and Jordan Henderson during Arsenal vs Liverpool explained
Arsenal line-ups vs PSV Eindhoven as Gabriel Jesus starts, no Tierney and youngster handed debut
Arsenal news and transfers LIVE: All the latest news, rumours and gossip from the Emirates Stadium