Argentina earned their first win over England at Twickenham for 16 years, condemning Eddie Jones' side to defeat in their opening game of the autumn campaign.
England eased their way to a 16-12 lead at half-time amid horrendous conditions in front of an 80,000 crowd, with Joe Cokanasiga scoring the only try of a physical first half.
But the hosts were unable to recover when Emiliano Boffelli and Santiago Carreras crossed in quick succession after the break to tilt the contest in favour of the visitors.