Antonio Conte has explained that three of his players who weren't included in the matchday squad against Brighton will also miss out against Southampton.
Spurs played Graham Potter's side in the FA Cup on Saturday and won 3-1, taking them to the next round of the competition, where they will travel to Middlesbrough.
The busy fixture schedule doesn't stop for the Lilywhites and they will have had just a few days to prepare for their next game, which is a return to the Premier League after the winter break.
