The Northern Ireland Air Ambulance charity has said it expects to deal with up to 60 calls over the month of December.
The Helicopter Emergency Medical Service (HEMS) will be available right through the month, with no break for the holidays.
It said that for every call it receives, that represents a critically ill or injured person and is asking the public to support its fundraising efforts.
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Glenn O'Rourke is the Operational Lead of HEMS and said their callouts begin to reflect the worsening conditions as winter progresses.
"For example, we may be called out to less sporting accidents at this time of year but more road traffic collisions," he said.
"Whatever has caused the critical emergency situation, our commitment to the public is to be there, day in, day out to look after the people of Northern Ireland.
"The doctors, paramedics and medical equipment is the provision and governance of the Northern Ireland Ambulance Service (NIAS), but it’s never taken for granted by our team the support from the public that enables us to fly to the sickest people who need us, on average twice per day.”
The charity is asking for people to help them with efforts to fund the service, with Head of Fundraising Kerry Anderson saying she recognised "times are difficult" for people.
"Any contribution this Christmas, will make a difference to a patient," she said.
"One of the simplest ways of supporting is by becoming a member of our Club AANI or you can buy this for a loved one, adults or children alike.
"Alternatively consider a stocking filler item from our online shop including Christmas Cards, Christmas tree baubles, dog bandannas or a beanie hat, or host a fundraiser at home or work like a Christmas Jumper Day.
"We also have e-cards available if you’d rather donate in lieu of sending cards."
For more information about Air Ambulance NI, visit their website.
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