
As the defending Super Bowl champions, the Los Angeles Rams get to open the 2022 season at home in the first game of the year. The NFL couldn’t have picked a much tougher opening opponent for the Rams, sending them the Super Bowl favorites in Week 1.
The Rams will host the Buffalo Bills at home next Thursday, Sept. 8. And although the Rams originally opened as 0.5-point favorites in that game when the schedule was released, the line has shifted dramatically. According to Tipico Sportsbook, the Rams are 2.5-point underdogs against the Bills.