St Kilda are waiting on scans for Jack Sinclair and Tom De Koning after the key duo were injured in a 22-point defeat to the Western Bulldogs at Marvel Stadium.
Smashed in their past three outings against the Bulldogs, the Saints were forced to deal with adversity from the start on Sunday when Sinclair went down in the first quarter and De Koning in the second.
St Kilda battled on bravely and stayed in the contest until late but the Bulldogs' early buffer was enough as they secured a crucial win, 12.11 (83) to 8.13 (61).
St Kilda initially insisted Sinclair hurt his calf, but there are fears it could be a more serious Achilles injury after his foot was put in a moon boot when he hobbled from the field in pain.