Justin McInerney will miss at least eight weeks with a hamstring injury, leaving premiership hopefuls Sydney without both of their star wingers.
McInerney could miss up to 10 weeks after being forced out of the club's two-point win over St Kilda late in the opening half with hamstring tightness.
The in-form midfielder had risen to new heights in injured Errol Gulden's absence, meaning the setback looms as a massive blow for the second-placed Swans (11-2).