Like most TTRPG actual-play series, Dimension 20 usually runs Dungeons & Dragons 5th edition—though they have recorded seasons where they roleplay using the Kids on Bikes and Kids on Broomsticks rules, as well as their own homebrew system. Their next season marks the first time they've partnered with a publisher to make official use of someone else's ruleset and setting, as they collaborate with White Wolf and Vampire: The Masquerade for a show called City Council of Darkness.
GMed by Brennan Lee Mulligan, the hardest-working man in actual-play, it's got an outstanding plot hook. The cast are all outcast vampires sent to the sticks to assert dominion over a town that's only just large enough to need its own undead representatives: Purpee, Oregon (population 18,000). "Between zoning disputes, bloodthirsty urges, and mandatory bake sales," says the official summary, "it's undead chaos in the quaintest hellscape imaginable."