Everyone knows someone who eats whatever they want and stays thin. A genetic study of more than a million people has now put an unusually precise number on one version of that: roughly 1 in 7,000 people carry a rare mutation that switches off a single copy of a gene called FNIP1, and those carriers show a metabolic profile most people would envy.
They have lower body fat, more lean mass, less liver fat, lower blood sugar, and around 60% lower odds of developing coronary artery disease, type 2 diabetes, or metabolic liver disease. The findings appeared in Nature on August 5 from a team led by the Regeneron Genetics Center.
