While PDRN is one of the most talked-about ingredients in skincare in 2026, not all formulas are made alike. You may know it from the injectable polynucleotide treatment, or the “salmon sperm facial”, which was popularised in South Korea.
Since then, the ingredient has made its way into more accessible topical solutions, which offer many of the same benefits, including barrier repair, hydration, cellular support and regeneration – but what are the best PDRN serums to shop now?