The Jacksonville Jaguars are hoping to put a Week 1 loss in the rearview mirror by beating a division rival in their home opener. But a lot has changed for the Indianapolis Colts since they lost to the Jaguars in Week 18 last season.
Former starting quarterback Carson Wentz is gone and former NFL MVP Matt Ryan is in his place. Indianapolis is also dealing with a few significant injuries with linebacker Shaquille Leonard out of action, and both DeForest Buckner and Michael Pittman Jr.
