DENVER—Psilocybin, the main psychoactive ingredient in magic mushrooms, can alleviate depression for at least five years after a single dose, a new study finds.
The research, presented June 18 at the Psychedelic Science 2025 conference in Denver, focused on patients with major depressive disorder (MDD), which is often called clinical depression. The serious mood disorder causes a persistent feeling of sadness and a loss of interest or pleasure in activities that were once enjoyable. The most common treatments for MDD include talk therapy and medications such as selective serotonin reuptake inhibitors, and both can take a long time to show any benefits.
